Histological and histochemical changes in the treatment of wounds with an injectable implant based on high-molecular hyaluronic acid and sodium succinate: Experimental study

  • Received 02.05.2025

  • Revised 22.07.2025

  • Accepted 02.09.2025



  • 588 Views

  • Retrieved from Vol. 7, No. 3, 2025

  • Pages 80-91

The aim of the study was to evaluate the effectiveness of an injectable implant combining hyaluronic acid and sodiumsuccinate for accelerating the reparative processes of donor wounds after autodermoplasty in patients with deep burns. The study was conducted from 1 January to 30 June 2014 in the Department of Combustiology of the Kharkiv Medical Academy of Postgraduate Education at the City Clinical Emergency and Urgent Care Hospital named after Prof. O.I. Meshchaninov, where in 50 patients with donor wounds after autodermoplasty the effectiveness of the hyaluronic acid and sodium succinate injectable implant and standard therapy was compared according to clinical, morphological andbiochemical parameters. The results showed that by the 10th day, complete healing was observed in 78% of patients inzone A (39 out of 50), while in zone B this indicator was only 6% (3 out of 50). By the 14th day, epithelisation wascompleted in 100% of cases in zone A, compared with 42% in zone B (21 out of 50). Morphological analysis showed a higher mitotic index in zone A – 16.1% versus 6.8% in zone B on the 10th day, which reflected more active cell renewal.Biochemical studies confirmed a more pronounced increase in catalase activity in zone A (from 28.2 to 36.6) compared with the control zone (from 25.8 to 27.4). Scars in zone A formed delicate and elastic, while in zone B dense and lessorganised structures predominated. The injectable implant of hyaluronic acid with sodium succinate accelerated healing and improved scar quality compared with standard therapy. The results obtained may be used by burn specialists, plastic surgeons and clinical pharmacologists in the practice of burn centres and departments of reconstructive surgery for optimising the treatment of donor wounds after autodermoplasty

donor site; regeneration; cell proliferation; collagen fibres; scars; antioxidant enzymes; tolerability

https://doi.org/10.63341/bmbr/3.2025.80
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