Influence of iodine deficiency state and influence of strumogenic products on organs of the cardiovascular system

  • Received 23.02.2026

  • Revised 01.04.2026

  • Accepted 27.04.2026

  • Published 29.05.2026


  • 1 View

  • Retrieved from Volume 8, No. 2, 2026

  • Pages 22-28

Currently, iodine deficiency diseases are a global medical and social problem: according to the WHO, various health disorders caused by iodine deficiency rank third among the 38 most common non-infectious diseases. The frequency of damage to the organs of the cardiovascular system and the prevalence of iodine deficiency is a prerequisite for studying the effect of thyroid imbalance on the heart and blood vessels. The goal was to follow the morphofunctional changes in the endocardium and the wall of arteries of different types in the dynamics of iodine deficiency development in postnatal ontogeny. The work was performed on experimental animals of sexually immature and sexually mature age. Achieving a state of iodine deficiency is confirmed by ioduria indicators and a thyroid profile. Both on the 60th day and on the 90th day of the iodine deficiency state, edematous changes occur in the connective tissue components, in the wall of blood vessels, especially in the endothelial layer, in all the examined organs, which was confirmed by light optical and electron microscopic research methods. Thus, the available data allow us to consider iodine deficiency as a systemic factor that can affect the cardiovascular system due to thyroid dysfunction. The combined intake of current-generating substances can increase this effect, especially if iodine deficiency has already formed.

experiment; rats; heart; arteries; metabolic disorders; morphological changes; microscopy; ontogenesis

https://doi.org/10.11603/bmbr.2706-6290.2026.2.16376
  1. Niwattisaiwong S, Burman KD, Li-Ng M. Iodine deficiency: clinical implications. Cleve Clin J Med. 2017;84(3):236-44. DOI: https://doi.org/10.3949/ccjm.84a.15053.
  2. Kukharchuk KhM. Clinical and epidemiological features of a subclinical hypothyroidism in young people. Health of Society. 2019;8(3):106-11. DOI: https://doi.org/10.22141/2306-2436.8.3.2019.192174. Ukrainian.
  3. Messina M, Redmond G. Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: A review of the relevant literature. Thyroid. 2006;16(3):249-58. DOI: https://doi.org/10.1089/thy.2006.16.249.
  4. Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, et al. Thyroid function within the normal range, subclinical hypothyroidism, and the risk of atrial fibrillation. Circulation. 2017;136(22):2100-16. DOI: https://doi.org/10.1161/CIRCULATIONAHA.117.028753.
  5. Otun J, Sahebkar A, Östlundh L, Atkin SL, Sathyapalan T. Systematic review and meta-analysis on the effect of soy on thyroid function. Sci Rep. 2019;9(1):3964. DOI: https://doi.org/10.1038/s41598-019-40647-x.
  6. Pankiv VI, Yuzvenko TYu. Relationships of subclinical thyroid dysfunction and metabolic syndrome. Clin Endocrinol Endocr Surg (Ukraine). 2017;2(58):39-43. DOI: https://doi.org/10.24026/1818-1384.2(58).2017.105577. Ukrainian.
  7. Peixoto de Miranda ÉJF, Bittencourt MS, Pereira AC, Goulart AC, Santos IS, Lotufo PA, et al. Subclinical hypothyroidism is associated with higher carotid intima-media thickness in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Nutr Metab Cardiovasc Dis. 2016;26(10):915-21. DOI: https://doi.org/10.1016/j.numecd.2016.06.005.
  8. Ranhulova T. Non-alcoholic fatty liver disease and hypothyroidism: review of clinical and experimental studies. Galician Medical Journal. 2021;28(4):E202142. DOI: https://doi.org/10.21802/gmj.2021.4.2.
  9. World Health Organization. Iodine Deficiency. Available from: https://www.who.int/data/nutrition/nlis/info/iodine-deficiency (accessed on 9 January 2022).
  10. Blum MR, Gencer B, Adam L, Feller M, Collet TH, da Costa BR, et al. Impact of thyroid hormone therapy on atherosclerosis in the elderly with subclinical hypothyroidism: A randomized trial. J Clin Endocrinol Metab. 2018;103(8):2988-97. DOI: https://doi.org/10.1210/jc.2018-00279.
  11. Skrypnyk NV. Metabolic syndrome and hypothyroidism: pathogenetic interrelations, diagnosis, and treatment. Diabetology, Thyroidology, Metabolic Disorders. 2017;1(37):60-3. Ukrainian.
  12. Anguiano B, de Oca CM, Delgado-González E, Aceves C. Prostate gland as a target organ of thyroid hormones: advances and controversies. Endocr Connect. 2022;11(2):e210581. DOI: https://doi.org/10.1530/EC-21-0581.
  13. Chakraborty A, Sarkar D, Dey P, Chandra AK. New insights into morphological, stereological and functional studies of the adrenal gland under exposure to the potent goitrogen thiourea. Interdiscip Toxicol. 2018;11(1):38-44. DOI: https://doi.org/10.2478/intox-2018-0005.
  14. Chandra AK, Mondal C, Sinha S, Chakraborty A, Pearce EN. Synergic actions of polyphenols and cyanogens of peanut seed coat (Arachis hypogaea) on cytological, biochemical and functional changes in thyroid. Indian J Exp Biol. 2015;53(3):143-51.
  15. Popadynets OH, Sahan OV, Barchuk RR, Voianskyi RS, Ananevych IM, Sahan NT, et al. Method for modeling iodine-deficient conditions with the addition of goitrogenic products. Patent of Ukraine No. 111647, 2016. Ukrainian.
  16. Bahrii MM, Dibrova VA, Popadynets OH, Hryshchuk MI. Methods of morphological research: A monograph. Bahrii MM, Dibrova VA, editors. Vinnytsia. Nova Knyha. 2016;328. Ukrainian.
  17. Hatch-McChesney A, Lieberman HR. Iodine and iodine deficiency: a comprehensive review of a re-emerging issue. Nutrients. 2022;14(17):3474. DOI: https://doi.org/10.3390/nu14173474.
  18. Zúñiga D, et al. Hypothyroidism and cardiovascular disease: a review. Cureus. 2024. DOI: https://doi.org/10.7759/cureus.52512.
  19. Patrizio A, et al. Hypothyroidism and metabolic cardiovascular disease. Front Endocrinol (Lausanne). 2024;15:1408684. DOI: https://doi.org/10.3389/fendo.2024.1408684.
  20. Babiker A, Alawi A, Al Atawi M, Al Alwan I. The role of micronutrients in thyroid dysfunction. Sudan J Paediatr. 2020;20(1):13-9. DOI: https://doi.org/10.24911/SJP.106-1587138942.
  21. Soetedjo NNM, et al. The impact of thyroid disorder on cardiovascular disease. Int J Cardiol Heart Vasc. 2024;55:101536. DOI: https://doi.org/10.1016/j.ijcha.2024.101536.
  22. Jin M, et al. U-shaped associations between urinary iodine concentration and the prevalence of metabolic disorders: a cross-sectional study. Thyroid. 2020;30(7):1053-65. DOI: https://doi.org/10.1089/thy.2019.0516.
  23. Inoue K, Leung AM, Sugiyama T, et al. Urinary iodine concentration and mortality among U.S. adults. Thyroid. 2018;28(7):913-20. DOI: https://doi.org/10.1089/thy.2018.0034.
  24. Maldonado-Araque C, Valdés S, Badía-Guillén R, et al. Iodine deficiency and mortality in Spanish adults: Di@bet.es Study. Thyroid. 2021;31(1):106-14. DOI: https://doi.org/10.1089/thy.2020.0131.
  25. Di Dalmazi G, Giuliani C. Plant constituents and thyroid: a revision of the main phytochemicals that interfere with thyroid function. Food Chem Toxicol. 2021;152:112158. DOI: https://doi.org/10.1016/j.fct.2021.112158.
  26. Galanty A, Grudzińska M, Paśko P. Do Brassica vegetables affect thyroid function? A comprehensive systematic review. Int J Mol Sci. 2024;25(7):3988. DOI: https://doi.org/10.3390/ijms25073988.
  27. Paśko P, Okoń K, Krośniak M, et al. Interaction between iodine and glucosinolates in rutabaga sprouts and selected biomarkers of thyroid function in male rats. J Trace Elem Med Biol. 2018;46:110-16. DOI: https://doi.org/10.1016/j.jtemb.2017.12.002.
  28. Paśko P, Prochownik E, Krośniak M, et al. Animals in iodine deficiency or sulfadimethoxine models of thyroid damage are differently affected by the consumption of Brassica sprouts. Biol Trace Elem Res. 2020;193:204-13. DOI: https://doi.org/10.1007/s12011-019-01694-7.
  29. Sobol LV, Kuibida IS, Harhaun OT, Popadynets OH. Structural features of the endocardium, arteries, prostate and adrenal glands under the conditions of iodine deficiency. Pol Merkur Lekarski. 2025;53(5):580-86. DOI: https://doi.org/10.36740/Merkur202505103.
  30. Sobol LV, Harhaun OT, Kuibida IS, Popadynets OH. The impact of iodine deficiency, combined with the using of thyroid gland function influenced products, on the organs of the cardio-vascular, endocrine, and reproductive systems. Wiad Lek. 2025;78(10):1981-87. DOI: https://doi.org/10.36740/WLek/213591.